Only variables with a p value <0.10 in univariate analysis (HF categories, non-solitary, MoCA, pulse, SBP, NYHA, abnormal JVP, diabetes mellitus, tobacco use, CKD, stroke, family history of HF, family history of coronary artery disease (CAD), cardiac hospitalization, Ischemic heart disease, ACEIs/ARBs and diuretics) or variables considered clinically relevant with outcomes (age, gender) were included in the backward stepwise multivariate analysis. The gene discussed is DOCK3; the disease is stroke disorder.