The initial site of cortical tau deposition appears to be transentorhinal cortex and lateral EC (Braak and Braak, 1985; Kaufman et al., 2018), which is consistent with other reports suggesting that alEC is particularly vulnerable to effects of age and preclinical AD (Berron et al., 2018; Khan et al., 2014; Reagh et al., 2018). Here, MAPT is linked to Alzheimer disease.