For a long time, ERβ has been considered to be an important factor in regulating metabolic pathways and adipose tissue function.14 In recent days, modulation of ERβ has raised more attention, not only due to its promising role in more applications,15 such as some types of cancer and neuropathies, but also because it has less side effects compared to activating estrogen receptor α (ERα). The gene discussed is ESR2; the disease is cancer.