Their observations were made in explanted ascending aortic SMCs from nonrelated familial TAAD or LDS patients with a TGFBR2 mutation, as opposed to ours in transdifferentiated SMC‐like cells of four related patients with the TGFBR1 mutation.(Inamoto et al., 2010) Nonetheless, our results are in line with the findings of Crosas‐Molist et al. showing increased expression of contractile protein markers in explanted SMCs from dilated ascending aortas of MFS patients in comparison with healthy controls. Here, TGFBR2 is linked to Marfan syndrome.