TGFBR1 and aneurysm: Another syndromic TAAD is the Loeys–Dietz syndrome (LDS) caused by mutations in transforming growth factor‐β receptor genes TGFBR1 (OMIM 190181) and TGFBR2. LDS was characterized initially by the triad of arterial tortuosity and aneurysms, hypertelorism, craniosynostosis and bifid uvula or cleft palate, including childhood onset aneurysms and dissections (Cozijnsen et al., 2011; Loeys et al., 2005, 2006).