Next, we have identified IGF1R, UBE3C, KMT2C, EPHB6, TRPV5, ESYT2, DPP6, PTPRN2, and CNTNAP2 reported to have de novo mutations in multiple (more than 2) independent cases with neurodevelopmental disorders, including ASD. The gene discussed is EPHB6; the disease is neurodevelopmental disorder.