Next, we have identified IGF1R, UBE3C, KMT2C, EPHB6, TRPV5, ESYT2, DPP6, PTPRN2, and CNTNAP2 reported to have de novo mutations in multiple (more than 2) independent cases with neurodevelopmental disorders, including ASD. This evidence concerns the gene TRPV5 and neurodevelopmental disorder.