REEP1 and neuronopathy, distal hereditary motor, type 5B: The first was a 58‐year‐old male (Patient ID 27) who underwent testing for suspected SPG, but who was finally diagnosed with spastic paraplegia 31 and distal hereditary motor neuronopathy type VB, caused by a mutation in REEP1. This gene is the third most common genetic cause of SPG (Zuchner et al., 2006), and it has been reported that a heterozygous splice site mutation can also cause autosomal dominant distal hereditary motor neuronopathy type VB (Beetz et al., 2008).