Recently, Moschovis D et al conducted a case–control study to investigate the contribution of two lncRNAs polymorphisms of PVT1 and HOTAIR, respectively, in PC susceptibility and demonstrated that the PVT1 polymorphism was significantly overrepresented in PDAC patients compared with the controls.83 These findings implied that chemoresistance to GEM may partly be induced by lncRNA processing to miRNAs.84 However, Li et al reported that other lncRNAs such as lnc‐HOTTOP were associated with GEM sensitivity in PDAC.85 Here, PVT1 is linked to pachyonychia congenita.