An et al proved that human ovarian cancer‐specific transcript 2 (HOST2), a long noncoding RNA, could promote GEM resistance in human pancreatic cancer cells and that downregulated HOST2 could inhibit cancer cell proliferation and induce apoptosis of pancreatic cancer cells (Table 3).82 Moreover, You et al demonstrated that GEM decreases PVT1 (oncogenic long noncoding RNA) levels but increases its encoded miRNAs (miR‐1207‐5p/miR‐1207‐3p). This evidence concerns the gene CERNA2 and pancreatic neoplasm.