NFKB1 and pachyonychia congenita: Horiuchi et al found that a potent NF‐κB inhibitor, nafamostat mesilate enhances the antitumor effect of GEM/nPTX chemotherapy for PC.33 Moreover, inhibition of tripartite motif containing 31 (TRIM31) could reduce NF‐κB signaling and subsequently inactivate various antiapoptosis genes, which can enhance GEM efficiency in PDAC.30