PDPK1 and neoplasm: As a common upstream activator, 3‐phosphoinositide‐dependent protein kinase‐1 (PDPK1) activates multiple downstream effectors and promotes the development of various diseases including cancer.24, 25 Pharmacologic and genetic inhibition of PDPK1 resulted in the regression of tumour growth in vitro and attenuated the tumorigenesis in tumour models in vivo.26, 27, 28 Thus, PDPK1 may represent a novel and rational therapeutic candidate for preventing cancer.29, 30, 31 Of note, there are only limited numbers of studies demonstrating the link between miR‐214‐3p, HOTAIR and PDPK1.