PDPK1 and cancer: Previously, we demonstrated an important role of PDPK1 in cancer growth with the implication that targeting PDPK1 may be a potential treatment of lung cancer.33, 37 In line with this, overexpression of PDPK1 in A549PDPK1+/+‐Luc cells not only showed more growth regression, it also significantly resisted the SM‐inhibited growth as compared with the wild‐type A549‐Luc cells (Figure 4A).