Previously, we demonstrated an important role of PDPK1 in cancer growth with the implication that targeting PDPK1 may be a potential treatment of lung cancer.33, 37 In line with this, overexpression of PDPK1 in A549PDPK1+/+‐Luc cells not only showed more growth regression, it also significantly resisted the SM‐inhibited growth as compared with the wild‐type A549‐Luc cells (Figure 4A). This evidence concerns the gene PDPK1 and lung cancer.