In line with this, HOTAIR was highly expressed in NSCLC cells and involved in cell migration, growth, invasion and metastasis.13, 43, 44, 45 The aberrant HOTAIR expression is expected to be considered as a potential biomarker for patients with NSCLC.46 We also observed the critical role of miR‐214‐3p as a tumour suppressor in mediating the effect of SM on NSCLC cell growth. This evidence concerns the gene HOTAIR and neoplasm.