Autocrine and paracrine of vascular endothelial growth factor A (VEGFA) have pro‐proliferative effects independently.20, 68 Myoferlin knockdown down‐regulated VEGFA secretion, which is caused by impairment of VEGFA exocytosis, subsequently, tumours lacked VEGFA and VEGFA induced functional blood vessels thus exhibited a reduced volume.36 In addition, myoferlin is required to maintain a branched mitochondrial structure and high oxidative phosphorylation activity. The gene discussed is MYOF; the disease is neoplasm.