Melanoma is the most aggressive type of skin cancer, and the appearance of vasculogenic mimicry (VM) in this type of cancer always indicates a poor prognosis.72 In VM, tumour cells mimic true vascular endothelium cells and form microvascular channels.73 Myoferlin knockdown significantly impaired the capability of A375 cells to form VM structures and subsequently inhibit cell invasion and migration in vitro. The gene discussed is MYOF; the disease is melanoma.