Exosomes, which are characterized by unique proteomic composition, participate in the intercellular exchange of metabolites, proteins and nucleic acids.51 Through proteomic analysis, myoferlin has been reported in several tumour‐derived exosomes, including prostate cancers,52 bladder cancers,53 colon cancers,54 ovary cancers,55 Hepatocellular carcinoma,56 squamous carcinoma cells57 and melanoma.58 Here, MYOF is linked to colonic neoplasm.