In total, 75%‐85% of liver cancer cases are hepatocellular carcinoma (HCC).62 HCC is often associated with poor prognosis.70 Hermanns et al44 demonstrated that myoferlin was necessary for invasion, proliferation and anchorage‐independent cell growth of HCC, and the myoferlin gene is targeted by MKL1/2. This evidence concerns the gene MYOF and hepatocellular carcinoma.