Myoferlin expression significantly correlates with the degree of histological differentiation of PAC, and reduced myoferlin expression alleviated malignant phenotypes of both primary and metastatic PAC cells.43 Exosomes have various roles in PDAC, mainly including local invasion, migration, immune evasion and therapeutic resistance.67 Myoferlin is critical for producing functional exosomes with sufficient quantities of certain components.41 This evidence concerns the gene MYOF and gonorrhea.