Latent HIV reservoirs in the host are established early before viral infection.45, 46 ACSS2, the crotonyl‐CoA‐producing enzyme acyl‐CoA synthetase short‐chain family member 2, was identified to influence HIV replication and viral latency by regulating histone crotonylation at HIV long‐terminal repeat.47 After histone crotonylation was induced by ACSS2 in vitro and ex vivo, HIV latency was disrupted. The gene discussed is ACSS2; the disease is viral infectious disease.