Again, while AdipoR1/AdipoR2 double-knockout mice were found to be associated with insulin resistance and impaired glucose tolerance, this was accounted for by increased inflammation and oxidative stress in major metabolic organs, such as the skeletal muscle, liver and adipose tissue, leading to increased gluconeogenesis and decreased glucose uptake in these mice (47). The gene discussed is ADIPOR2; the disease is Impaired glucose tolerance.