•TEAD, YAP, and TAZ expression in human reproductive tissues (https://www.proteinatlas.org)•Impaired pregnancy-induced mammary tissue growth in MMTV-Cre; Yapflox/flox mice (Chen et al., 2014)•Human genetic disorders and abnormal developmental phenotypes (including embryonic lethality) in mice with germline deletion of key Hippo pathway effectors. Here, WWTR1 is linked to hereditary disease.