SMCO2 and neoplasm: Genes in the top 10 downregulated category are found to act as tumor suppressors [SMCO2 (51), CCBE1 (50)], increase responsiveness to chemotherapy [SLC22A6 (52–54), SLC5A5 (55)], serve as prognostic markers [CCBE1 (56)], and play a role in cellular differentiation [KRT24 (57), CCBE1 (50)].