The genes RRM2, UBE2C, LMX1A, HOXC10, and SIM2 have previously been evaluated in glioma and are shown to protect glioma cells from replication stress, DNA damage, and apoptosis [RRM2 (36)], to be associated with decreased overall length of survival and increased tumor aggressiveness [UBE2C (41)], to contribute to tumor immunosuppression [HOXC10 (31)] and to promote glioma migration and invasion [HOXC10 (31), SIM2 (32, 34)]. This evidence concerns the gene RRM2 and central nervous system cancer.