SIM2 and cancer: In this study, we demonstrate that the top 10 genes found to be upregulated in canine ODG contribute to cancer treatment resistance [RRM2 (23), KIAA0101 (24), HOXC10 (25, 26)], migration [KIAA0101 (24, 27)], invasion/metastasis [LBX1 (28), HOXC10 (29–31), SIM2 (32–34)], and cancer cell survival [RRM2 (35, 36), IRX5 (37, 38), UBE2C (39)].