SMPX and central nervous system cancer: Figure 4B shows the expression level of the downregulated genes in human ODG, OA, AA, and GBM compared to normal brain tissue (NT). SMPX, CCBE1, and SLC5A5 demonstrated significant downregulation across all subtypes of human glioma with a p ≤ 0.0001, whereas SLC22A6 (p < 0.0001) and KRT24 (p ≤ 0.008) were shown to be downregulated only in human GBM. C7orf72 (Ortholog of Canine C18H7orf72/SPATA48) was not found to be downregulated in human GBM but did demonstrate significant downregulation in human ODG (p ≤ 0.01) and OA (p < 0.006).