CD2 and central nervous system cancer: In glioma, these genes are involved in mediating tumor migration [CD70 (82)], angiogenesis [CD93 (94), CD36 (93, 95)], T-cell activation [CD2 (92)], maintenance of glioma stem cell populations [CD36 (96)], tumor proliferation [CD74 (97)], and TMZ resistance [CD74 (97)].