We demonstrated that the top 10 CD genes upregulated in canine glioma are involved in influencing immune response through stimulation of dendritic cell-T cell interactions [CD209 (73–75) CD101 (76, 77)], T-cell activation [CD70 (78), CD101 (76, 77), CD2 (79–81)], the promotion of an immunosuppressive tumor microenvironment [CD70 (82), CD163 (83, 84)], stimulation of angiogenesis [CD163 (83, 84), CD93 (85, 86) CD74 (87, 88)], and regulation of monocytes and macrophages [CD36 (89, 90)]. The gene discussed is CD2; the disease is glioma.