CASP8 and cervical cancer: To validate these findings regarding the prognostic role of PLK3, we analyzed TCGA data from cervical cancer (CESC) patients and while there were no differences in metastasis and overall survival for Caspase 8 gene expression and OS for PLK3 gene expression, we found a significant association between low PLK3 gene expression and poor metastasis-free survival (p = 0.019) (Figure 4).