CASP8 and anal carcinoma: However, in contrast to a recent investigation in anal carcinoma treated with definitive RCT (22), we did neither recognize a significant correlation of p16INK4a with PLK3 and a borderline significance with pT273 Caspase 8 expression (Table 2), nor did we observe a significant impact of PLK3 and pT273 Caspase 8 detection on the incidence of local failure (Figures 2, 3).