The data showed that systemic lupus erythematosus pathway was significantly down-regulated and suggest the several signaling pathways associated with NLRP3 inflammasome activation on MAPK, ECM-receptor interaction, cell adhesion molecules, Toll-like receptor, FcγR-mediated phagocytosis and leukocyte transendothelial migration may all contribute to the mechanism of action of the potential renoprotective effects of M1 in the treated ASLN mice (Supplementary Table S1). The gene discussed is NLRP3; the disease is systemic lupus erythematosus.