Moreover, autophagy exerts an inhibitory effect on the NLRP3 inflammasome and can negatively regulate the innate immune response and inflammation (23, 33), for which various studies suggest that autophagy serves as a negative regulator of the NLRP3 inflammasome in the restoration of tissue homeostasis after damage in autoimmune diseases, including LN (34–36). This evidence concerns the gene NLRP3 and autoimmune disease.