The NOD-like receptor family-pyrin domain containing 3 (NLRP3) inflammasome, which controls the activation of caspase-1 and in turn cleaves pro-IL-1β and pro-IL-18 to form mature IL-1β and IL-18 (17–19) has emerged as a key player in inflammatory responses and the induction of adaptive immunity, and it has garnered support as being important in promoting LN progression (19, 20). Here, NLRP3 is linked to lobular neoplasia.