IL18 and lobular neoplasia: The NOD-like receptor family-pyrin domain containing 3 (NLRP3) inflammasome, which controls the activation of caspase-1 and in turn cleaves pro-IL-1β and pro-IL-18 to form mature IL-1β and IL-18 (17–19) has emerged as a key player in inflammatory responses and the induction of adaptive immunity, and it has garnered support as being important in promoting LN progression (19, 20).