SMPDL3B and focal segmental glomerulosclerosis: Recent research showed that rituximab binds sphingomyelin phosphodiesterase acid-like 3b (SMPDL-3b) protein, resulting in preservation of podocyte SMPDL-3b expression, preventing podocyte apoptosis, and maintaining the integrity of podocyte actin cytoskeleton, therefore highlighting the biological rationale of this therapy in patients with FSGS independent of its effect on B cells (91).