Since we observed increased PD-1 expression on TILs and PD-L1 expression on tumors cells following HER2-DC1 vaccination in TUBO bearing mice, we investigated whether blockade of immune checkpoints, PD-1 or PD-L1 in combination with HER2-DC1 vaccine would enhance the anti-tumor immune response in TUBO bearing mice. The gene discussed is ERBB2; the disease is neoplasm.