Importantly, TUBO bearing mice that received Class I (p66) HER2 peptide pulsed DC1 in combination with anti-PD-1 antibody had significant delay in tumor growth and doubled the survival rate in TUBO bearing mice, compared to mice that received single treatment or no treatment (Figures 5B,C, p < 0.01). This evidence concerns the gene ERBB2 and neoplasm.