Class I (p66) HER2-DC1 vaccine in TUBO bearing mice led to a significant increase in tumor infiltrating CD8+ T cells but not CD4+ T cells, while class II HER2-DC1 vaccine significantly increased both CD4 and CD8+ T cell infiltration compared to untreated controls (Figures 3D,E, p < 0.001). The gene discussed is ZDHHC4; the disease is neoplasm.