To explore whether the NLRP3 inflammasome/IL-β was involved in the reduction of AQP1 and AQP2 expression in the kidneys, mice were treated with MCC950 and Anakinra during ZIKV infection, which are NLRP3 inflammasome inhibitor and IL-1β receptor antagonist, respectively. The gene discussed is NLRP3; the disease is Zika virus infectious disease.