BCL2 and Zika virus infectious disease: ZIKV infection reduced the expression level of Bcl-2 in HK-2 cells, whereas cells transfected with Bcl-2 plasmid significantly enhanced Bcl-2 expression in both mock or ZIKV-infected HK-2 cells, which confirmed the efficiency of the protocol of Bcl-2 overexpression (Figures 7D,E).