As shown in Figure 2M, while the frequency of CD8+ CD161int T cell subsets did not differ in the two study groups, that of CD161high T cells among all CD8 T cells was strongly reduced or completely lost in progressive MS (Mean ± SEM Ctrl vs. PP-MS 7.07 ± 1.83 vs. 2.03 ± 0.53, p-value 0.02) and this evidence was reproduced in the effector and central memory CD8 T cell compartment (Mean ± SEM Ctrl vs. PP-MS, EM 21.78 ± 5.34 vs. 7.24 ± 2.07, p-value 0.02; CM 7.10 ± 1.83 vs. 0.99 ± 0.26, p-value 0.0001). This evidence concerns the gene CD8A and myeloid sarcoma.