Notably, the observations that CD161-expressing CD8+ or Vα 7.2+ T cells infiltrate MS lesions and bear an inflammatory phenotype (9, 24, 25), and that autologous hematopoietic stem cell transplantation in subjects with aggressive, highly inflammatory MS depletes circulating MAIT cells for several years (30), support the hypothesis of a pathogenic role for these cells in MS. The gene discussed is CD8A; the disease is myeloid sarcoma.