ANXA2 and age-related macular degeneration: Here, we noted the presence of systemic circulating autoantibodies to Cryaa, Cryab, Ubiquitin-B, and Annexin 2 in the serum of aged CXCR5−/− mice; these findings are consistent with those in recent studies by Iannaccone et al. (51) in human AMD patients and with other studies demonstrating the upregulation of Cryaa and Cryab in Bruch's membrane and the choroidal tissues of AMD patients (24, 25).