CD4 and autoimmune disease: To verify that MALT1 enzymatic activity in other cells not targeted by CD4-Cre may still contribute to the development of autoimmune disease, we generated Malt1PD/−Rosa26LSL-MALT1-WTCD4-Cre mice in which all cells endogenously express protease-dead MALT1, and where human WT MALT1 is specifically expressed as a transgene in cells that have experienced CD4-Cre activity.