Immune deficiency may be related to several genes, especially Platelet-derived growth factor alpha (PDGFalpha), caspase recruitment domain 11 (CARD11), N-acetylglucosaminyltransferase lunatic fringe (LFNG), MafK, and G protein-coupled estrogen receptor 1 (GPER-1). Here, LFNG is linked to Immunodeficiency.