HMGB1 and cancer: T cell immunoglobulin and mucin-domain containing-3 (Tim-3), which can binds to galectin-9, carcinoembryonic antigen cell adhesion molecule 1 (Ceacam1), high-mobility group box 1 (HMGB1) or phosphatidylserine (PtdSer), is another immunoregulatory molecule highly expressed on NK cells with relevance for NK cell function in both HIV and cancer (40–47).