Tumor progression has been associated with lower levels of NKG2D (as well as NKp30 and NKp46) expression on NK cells from patients with cervical cancer (102), and defective NK cell function owing to NKG2D downregulation has been linked to high-risk myelodysplastic syndrome (MDS) (103). The gene discussed is KLRK1; the disease is myelodysplastic syndrome.