NFKBIA and viral infectious disease: Indeed, both Western blotting and immunofluorescence staining showed increased IKBα and decreased nuclear p65 form of NFκB in IAV-infected SOCS3-knockdown cell and lung of TG mice as compared to WT host, suggesting that silencing SOCS3 may result in a suppression of NFκB upon viral infection (Figures 6B–D).