MMP9 and neoplasm: In Rip1-Tag2 pancreatic insulinoma, L929 fibrosarcoma, B16-F10 melanoma, LLC, HPV-15-induced squamous carcinoma, HT-1080 fibrosarcoma, and PC-3 human prostate carcinoma, neutrophils infiltrated to the tumors majorly secrete MMP9 remodeling the ECM to release VEGF and FGF-2, and activating them to trigger chronic angiogenesis and thereby promotes tumor progression (99–102, 135).