These neutrophils represent a tumor-promoting transcriptional profile with upregulated expression of genes associated with angiogenesis (VEGFA, HIF1α, and SEMA4d), myeloid cell differentiation and recruitment (CSF1, CCL3, and MIF), extracellular matrix remodeling (ADAMDEC1, ADAM17, and many cathepsins), T cell suppression (PD-L1, FCGR2b, and HAVCR2), and tumor cell proliferation (TNF, TGFβ1, and IL-1α) (152). This evidence concerns the gene ADAM17 and neoplasm.