CD40 and pancreatic adenocarcinoma: Meanwhile, Ly6Chi monocyte infiltration into KPC pancreatic adenocarcinoma via IFN-γ and CCL2 following anti-CD40 treatment has been reported to facilitate degradation of tumor fibrosis, increasing the efficacy of the chemotherapy on PDAC while Ly6Chi monocyte-containing Gr-1+ myeloid cells in HCC play pro-fibrotic roles (33, 40, 55).