ANGPT2 and cancer: Meanwhile, Collagen triple-helix repeat-containing 1 (CTHRC1) secreted by several malignant tumors has been reported to recruit TEMs to the tumor microenvironment through upregulation of Ang-2 in endothelial cells and promote metastasis in human MiaPaCa-2, CFPAC-1, and Panc-1 pancreatic cancers (69).