In vitro study of BGC-823, MGC80-3, SGC-7901, and HGC-27 human gastric cancer cells has elucidated that interaction between HMGB1 secreted by the cancer cell-derived exosomes and toll-like receptor 4 (TLR4) on neutrophils fosters the formation of the autophagosome, inhibition of ROS production, and upregulation of MMP9 and VEGF in neutrophils, inducing polarization of neutrophils, promoting cancer cell migration (158). This evidence concerns the gene HMGB1 and cancer.