Coculture of gastric cancer patient-derived neutrophils and human MKN45, MKN74 gastric cancer cells has proven that IL-17α activates JAK2/STAT3 axis in the cancer cells following by their acquisition of mesenchymal characteristics, and the IL-17α is mostly derived from tumor-associated neutrophils (TANs) (108). Here, STAT3 is linked to neoplasm.