CCL2 and neoplasm: Clinical trials conducted for Carlumab in ovarian cancer, prostate cancer and other solid tumors with and without other chemotherapies such as docetaxel, gemcitabine, paclitaxel+carboplatin, or PLD has proven that Carlumab is well-tolerated but unfortunately fails to trigger significant tumor responses, since it could not sustain the long-term blockade of CCL2 (182–184).