IFNG and tuberculosis: As for immunodiagnostic assays, both the tuberculin-skin-test (TST) and interferon-gamma release assays (IGRAs)—that measure cell-mediated immune responses following M. tuberculosis infection—are unable to distinguish between active TB and LTBI (Latorre and Domínguez, 2015) and limit the accuracy of M. tuberculosis detection (Dominguez et al., 2009; Velasco-Arnaiz et al., 2018).