Nr3c1Pax8/LC1 mice with lacking GR in renal tubular cells (Figure 1 and Supplementary Figure S1) show no obvious phenotype (Figure 2 and Supplementary Figure S3) contrarily to the MR (Nr3c2Pax8/LC1) knockout mice which developed severe pseudohypoaldosteronism type 1 (PHA-1) under standard Na+ diet that worsened upon Na+-deficient diet (Canonica et al., 2016; Terker et al., 2016). Here, NR3C2 is linked to pseudohypoaldosteronism type 1.