Indeed, tyrosol suppressed the level of mitochondrial ROS induced by hyperglycemia (Figure S1A), most plausibly by restoring the expression level of Ndufaf1 (Figure S1B), a member of complex I of electron transport chain whose expression is disrupted in HO-1-/- mice (Suliman et al., 2017). Here, HMOX1 is linked to Hyperglycemia.