Overall, our results demonstrated that intramuscular tyrosol administration could induce the formation of mature, functional blood vessels in diabetic HLI mice, plausibly by enhancing the expression of HO-1 thereby protecting skeletal muscle cells from hyperglycemia-induced oxidative stress, leading to an increase in skeletal muscle cell number, secreted angiogenic factors, and migration capability. The gene discussed is HMOX1; the disease is Hyperglycemia.