In this study, we found that tyrosol induces the expression of the cytoprotective factor heme oxygenase-1 (HO-1) in skeletal muscle cells under hyperglycemia, which is crucial for oxidative stress protection (Iori et al., 2008; Gou et al., 2018), and concomitantly decreases hyperglycemia-induced accumulation of intracellular reactive oxygen species (ROS). The gene discussed is HMOX1; the disease is Hyperglycemia.