VEGFA and Hyperglycemia: However, hyperglycemia induces systemic disruption of physiological functions, such as angiogenesis, by suppressing the expression of various crucial angiogenic factors, such as the vascular endothelial growth factor-A (VEGF-A) (Avogaro et al., 2011; Caporali et al., 2015) and the platelet-derived growth factor-BB (PDGF-BB) (Tanii et al., 2006).