Recently, Dalbeth et al. confirmed that combination of colchicine and CYP3A4 inhibitors, such as cyclosporin, tacrolimus, and imidazole, may increase intracellular accumulation of colchicine, which can lead to increased infections (Dalbeth et al., 2014; Stack et al., 2015). The gene discussed is CYP3A4; the disease is infection.