EGFR and triple-negative breast carcinoma: In the European Union, aside from the previously mentioned indications, the EMA also approved Avastin® in combination with EGFR tyrosine kinase inhibitors as first-line therapy in EGFR-mutant NSCLCs, and first-line treatment in combination with paclitaxel or capecitabine (if paclitaxel-intolerant) for triple-negative breast cancer.