MEF2C and hepatocellular carcinoma: Although the anabolic roles of canonical Wnt/β-catenin signaling pathway in the bone were identified (Tu et al., 2015) and MEF2C/β-catenin complex was detected in hepatocellular carcinoma and myoblasts (De Angelis et al., 1998; Bai et al., 2015), siMEF2C or SB239063 was shown to have little effect on anti-/pro-anabolism of osteogenesis in vitro (data not shown).