MECP2 and epilepsy: Ingenuity © analysis revealed a strong association of DE genes with neuronal diseases such as seizures, motor dysfunction and epilepsy (Figure 2D), all are relevant to the phenotypes associated with diseases causes by Lis1 and MeCP2. This global trend was also observed for genes DE in MeCP2−/y neurons and was preserved in the double mutants (Figure 2D).