Indeed, aggregation of misfolded SOD1 proteins is a common pathological observation among subjects with different SOD1 mutations and is, therefore, believed to be central to ALS pathogenesis (Bruijn et al., 1998; Wang et al., 2005; Prudencio et al., 2009; Abu-Hamad et al., 2017; Shvil et al., 2018). Here, SOD1 is linked to amyotrophic lateral sclerosis.