In addition, neurofibrillary tangle (NFT) formation is tightly correlated with the phosphorylation of tau at Thr212/Ser214 (AT100) and Thr 231 (AT180) and can induce many neurodegenerative diseases (Augustinack et al., 2002; Congdon and Sigurdsson, 2018). This evidence concerns the gene MAPT and Neurofibrillary tangles.