SNCA and Insulin resistance: Indeed, while Rodriguez-Araujo et al. (2015) suggest that absence of alpha-synuclein in mice is associated with impairment in glucose metabolism during HFD-induced insulin-resistance, Geng et al. (2011) show an increased rate of insulin secretion in alpha-synuclein knockout mice, indicating alpha-synuclein as negative regulator of insulin secretion.