For instance, it lacks the completeness of Aβ-PET, APOEε4, cerebrospinal fluid tau or Aβ examinations, given that only ∼60% of the included population had genetic tested and Aβ-PET undertaken; and (5) finally, other related biomarkers and imaging approaches need to be investigated to gain more understanding of SCD (plus). The gene discussed is MAPT; the disease is Schnyder corneal dystrophy.