A recent study that genotyped MMP-2-1306 T/C and MMP-9-1562 C/T in a relatively large cohort of CSVD patients and controls came to a similar conclusion that MMP-2-1306 T/C polymorphism was associated with moderate or severe leukoaraiosis (Zhang et al., 2015). This evidence concerns the gene MMP2 and Abnormal cerebral white matter morphology.