JAK2 and posterior cortical atrophy: We found that PA treatment did not affect JAK2 phosphorylation at Y1007/1008 residues (Supplementary Fig. S1A), EGFR phosphorylation at Y845/Y992/Y1068/Y1148 residues (Supplementary Fig. S1B), and ERK phosphorylation (Supplementary Fig. S1C), suggesting that the enhanced STAT3 phosphorylation in PCa is not due to enhanced JAK, EGFR, and ERK activities.