Experimental evidence suggest that several classes of antihypertensive drugs have anticancer properties (e.g., inhibition of pancreatic stellate cells, a key player in pancreatic carcinogenesis, by drugs acting on the renin–angiotensin system and induction of pancreatic cancer cell apoptosis by beta-blockers).2,3 Thus, antihypertensive drugs may have multiple effects on pancreatic carcinogenesis, which could decrease the risk of pancreatic cancer in patients with chronic pancreatitis and improve survival in patients with pancreatic cancer. The gene discussed is REN; the disease is familial pancreatic carcinoma.