REN and pancreatic neoplasm: Experimental evidence suggest that several classes of antihypertensive drugs have anticancer properties (e.g., inhibition of pancreatic stellate cells, a key player in pancreatic carcinogenesis, by drugs acting on the renin–angiotensin system and induction of pancreatic cancer cell apoptosis by beta-blockers).2,3 Thus, antihypertensive drugs may have multiple effects on pancreatic carcinogenesis, which could decrease the risk of pancreatic cancer in patients with chronic pancreatitis and improve survival in patients with pancreatic cancer.