In addition, immunohistochemical detection of CD31 in the tumours generated by OCI-Ly12 injection showed a significantly low microvessel density in the DA+CHOEP-treated group, as compared with the other cohorts of mice (untr 4.8 ± 0.68, DA 3.2 ± 0.39, CHOEP 2.8 ± 0.44, DA+CHOEP 0.8 ± 0.42; mean ± SEM of the number of vessels/field) (Fig. 6c). Here, PECAM1 is linked to neoplasm.