The in vivo anti-tumour activity of the combination DA+CHOEP was investigated in two localised human tumour xenografts models in NOD/SCID mice developed using subcutaneous injection of HD-MAR-2 (the least sensitive cell line) and OCI-Ly12, the PTCL cell line, which in in vitro experiments was among the most sensitive to CHOEP. This evidence concerns the gene PEG10 and neoplasm.