We identified that miR-G-10 binds to the 3′ UTR of TIMP3 and PIK3R3 transcripts, and miR-G-10 downregulates TIMP3 in classic AGO2-dependent manner, whereas upregulates PIK3R3 in a GRSF1-dependent manner, and promotes migration/invasion and metastasis in cervical cancer. The gene discussed is PIK3R3; the disease is cervical cancer.