eIF5A and its hypusination are essential for cellular growth in cultured cells (Park et al., 1994) and early embryonic development in mice (Nishimura et al., 2012), but its tissue-specific function is still unclear, although inducible whole-body KO of Dhs in mice leads to a fatal wasting syndrome (Pällmann et al., 2015). This evidence concerns the gene DHPS and Cachexia.