Among signaling pathways showing the greatest correlation for genes co-expressed with ANXA8, hsa04151 (PI3K-Akt signaling pathway), hsa05205 (proteoglycans in cancer), hsa05200 (pathways in cancer), hsa04510 (focal adhesion), hsa04512 (ECM-receptor interaction), and hsa04020 (calcium signaling pathway) were correlated with the tumorigenesis and progression of tumors (Fig. 10a). The gene discussed is AKT1; the disease is cancer.