Yoshihara et al. found that ANXA5 (P = 1.77E−9, fold change = − 3.973) and ANXA6 (P = 4.86E−14, fold change = − 5.732) were downregulated in ovarian serous adenocarcinoma compared with the peritoneum [25], which was confirmed by Bonome et al. and Welsh et al. [22, 23]. The gene discussed is ANXA6; the disease is ovarian serous adenocarcinoma.