In addition, KMT2D (also known as MLL2 or MLL4) is a member of the SET1 family of histone methyltransferases (HMTs) that facilitates the establishment of H3K4me2/me1 at enhancer regions and was frequently found to be mutated in FL (accounting for 70–80% of cases) and DLBCL [122–124]. Here, KMT2D is linked to diffuse large B-cell lymphoma.