It is noteworthy that mice with miR-155 overexpression in a B cell-specific manner develop high-grade B-cell lymphoma resembling diffuse large B-cell lymphoma (DLBCL) [59], likely owing to the effect of miR-155 on SHIP1, which promotes TNFα-dependent cell proliferation [60]. The gene discussed is INPP5D; the disease is diffuse large B-cell lymphoma.