CLCN5 and nephrocalcinosis: Thus, loss of ClC‐5 function in this segment may contribute to nephrocalcinosis risk.22, 23, 24 The role of ClC‐5 in mTAL remains circumstantial and speculative.25 Studies suggest that endocytosis takes place in murine mTAL where V‐ATPase is also present26 albeit at a lesser extent than in PTCs, thus suggesting a possible role for ClC‐5 during endocytosis and exocytosis processes in this nephron segment.