NHERF1 and Hypercalciuria: However, the significance of these findings is still not clear, since NHERF1 or NHERF2 KO mice lacked LMWP, the hallmark of ClC‐5 dysfunction.39 Intriguingly, however, NHERF1 null mice manifest decreased apical membrane NaPi2a, hyperphosphaturia and hypercalciuria.