Severe frailty was observed in 29.5% of the study group, significantly more frequently in the no-OAC group, and severe frailty and anemia were the independent negative determinants of OAC prescription at discharge when adjusted for albumin level < 35 g/L, HAS-BLED ≥ 3 and CHA2DS2-VASc score. This evidence concerns the gene ALB and anemia.