REN and Hyperglycemia: Despite multifactorial treatment aimed at reducing established renal risk factors (including dietary advices to reduce overweight, smoking cessation, amelioration of hyperglycemia, blood pressure- and albuminuria-lowering by blockers of the renin–angiotensin–aldosterone (RAS) system and lipid-lowering by statins) residual risk to develop ESKD remains high [23].