APOH and brain injury: In addition, β2GPI has been detected in brain and gut endothelium of mice challenged with lipopolysaccharide (LPS) [33], as well as in the brain of mice undergoing ischaemic brain injury [38], although in this latter study, a faint signal was seen for β2GPI in the brains of sham controls suggesting that β2GPI is present in non-ischaemic brain tissue.