NF2 and meningioma: For instance, NF2/chr22loss meningioma meningiomas typically originate from the lateral regions and posterior fossa, while the vast majority of non-NF2 meningiomas commonly harbor location-specific mutations in SMO (olfactory groove), KLF4/TRAF7 (medial skull base), and AKT1/TRAF7 (anterior skull base) [1, 6, 9, 20].