GSE1, also known as KIAA0182, has been shown to possess oncogenic properties in human breast cancer cells and gastric cancer and accelerates tumorigenesis in neuroepithelial stem cells of Gorlin syndrome patients, who are predisposed to medulloblastoma due to PTCH1 mutation [7, 14, 24]. This evidence concerns the gene PTCH1 and nevoid basal cell carcinoma syndrome.