Next, we focused on the most common genetic alterations reported so far in meningiomas, including the NF2, SMARCB1, as well as TRAF7, AKT1, SMO, KLF4, PIK3CA, and TERT in non-NF2 mutated meningiomas (Fig. 3) [51]. The gene discussed is PIK3CA; the disease is meningioma.