They confirmed that overgrowth (including height and occipito-frontal circumference), dysmorphism, and learning disabilities were present in 90% of these NSD1-positive individuals, with a wide spectrum of associated features including macrocephaly, advanced bone age, neonatal jaundice and hypotonia, seizures, scoliosis, cardiac defects, and genitourinary anomalies [31]. Here, NSD1 is linked to scoliosis.